肠道菌群对高脂血症调控机制及治疗新方法研究进展

孙建锋1,董文婷1,张 2,霍金海1*,王伟明1*

1.黑龙江省中医药科学院中药研究所,黑龙江哈尔滨 150036

2.黑龙江省疾控预防控制中心,黑龙江哈尔滨 150030

摘要:高脂血症是一种由脂质代谢失调引起的疾病,能够诱发高血压、高血糖、脑卒中、心肌梗塞等心脑血管疾病。大多数对高脂血脂症的研究都是以脂肪代谢为中心展开的。目前研究发现,高脂血症患者体内肠道菌群的结构和多样性会发生改变,同时,肠道菌群紊乱亦会影响机体的脂质代谢。本文详细阐述了肠道菌群对高脂血症的调控机制,并对益生菌及益生菌发酵食品对高脂血症治疗作用进行整合分析,为发现治疗高脂血症新的靶点提供科学依据。

关键词:肠道菌群;高脂血症;益生菌;发酵食品

中图分类号:Q935   文献标识码:A   文章编号:1674-506X202103-0115-0005


The Regulation Mechanism and New Treatment Progress of Intestinal Flora to Hyperlipidemia

SUN Jian-feng1, DONG Wen-ting1, ZHANG Xu2, HUO Jin-hai1*, WANG Wei-ming1*

1.Heilongjiang Academy of Chinese Medical Sciences, Harbin Helongjiang 150036, China;

2.Heilongjiang Provincial Center for Disease and Prevention, Harbin Helongjiang 150030, China

AbstractHyperlipidemia is a type of disease caused by lipid metabolism disorders, which can induce hypertension,  hyperglycemia, stroke, myocardial infarction and other cardiovascular diseases. Most studies of hyperlipidemia are centered on fat metabolism. Current studies have found that the structure and diversity of intestinal flora in patients with hyperlipidemia will change, and intestinal flora disorders will also affect the body’s lipid metabolism. This paper elaborates the regulation mechanism of intestinal flora on hyperlipidemia in recent years, and the probiotics and probiotics fermented food on the treatment of hyperlipidemia were integrated analysis, providing a scientific basis for finding new targets for the treatment of hyperlipidemia.

Keywordsintestinal flora; hyperlipidemia; probiotics; fermented food

doi10.3969/j.issn.1674-506X.2021.03-018


收稿日期:2020-10-31

基金项目:现代农业产业技术体系建设专项资金资助项目(NO CARS-21);哈尔滨市应用技术研究与开发项目(No 2017RGAYJ009

作者简介:孙建锋(1993-),男,硕士研究生。研究方向:中药分析。

*通信作者

引用格式:孙建锋,董文婷,张旭,.肠道菌群对高脂血症调控机制及治疗新方法研究进展[J].食品与发酵科技,2021,57(3):115-119.


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